Structure information

GPR61

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9YFU

SPECIES

Homo sapiens

RESOLUTION

3.080

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

March 25, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
GPR61 inverse agonist 15 N137 3.47x47 TM3 polar (hydrogen bond)
GPR61 inverse agonist 15 N137 3.47x47 TM3 polar (hydrogen bond)
GPR61 inverse agonist 15 N137 3.47x47 TM3 Van der Waals
GPR61 inverse agonist 15 R140 3.50x50 TM3 polar (charge-assisted hydrogen bond)
GPR61 inverse agonist 15 V227 5.57x57 TM5 hydrophobic
GPR61 inverse agonist 15 V227 5.57x57 TM5 Van der Waals
GPR61 inverse agonist 15 M231 5.61x61 TM5 Van der Waals
GPR61 inverse agonist 15 V354 6.35x35 TM6 Van der Waals
GPR61 inverse agonist 15 V355 6.36x36 TM6 Van der Waals
GPR61 inverse agonist 15 V355 6.36x36 TM6 hydrophobic
GPR61 inverse agonist 15 V359 6.40x40 TM6 hydrophobic
GPR61 inverse agonist 15 V359 6.40x40 TM6 Van der Waals
GPR61 inverse agonist 15 L411 ICL4 polar (hydrogen bond with backbone)
GPR61 inverse agonist 15 L411 ICL4 Van der Waals
GPR61 inverse agonist 15 N412 8.47x47 H8 polar (hydrogen bond)
GPR61 inverse agonist 15 N412 8.47x47 H8 Van der Waals

Ligands

GPR61 inverse agonist 15

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Residue Diagrams

A N G A V A T L D L L L M F F L A V S E 1 F H L C L V D L L A A T L L M P L A M L S 2 A S V S L I A L S V F C V S L F L Y L R 3 V A S V L V G V W V K A L A M A S V P V 4 Y V V L I L L L P L L F Y L V A F V V V F 5 L A V G G Q F L L C W L P Y F S F H L Y 6 F P N S T F C F Y G I W T V V S E V Q 7
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ICL1 P A L R ICL1ECL1 F D H A L ECL1ICL2 P M R Y E V R M ICL2ECL2 E G A P S V P P G C S L Q W S H ECL2ICL3 T W M E T P R Q R S E S L S S R S T M V T S S G A P Q T T ICL3ECL3 A Q P I S ECL3N-term M E S S P I P Q S S G N S S T L G R V P Q T P G P S T A S G V P E V G N-termC-term C F F K P A P E E E L R L P S R E G S I E E N F L Q F L Q G T G C P S E S W V S R P L P S P K Q E P P A V D F R I P G Q I A E E T S E F L E Q Q L T S D I I M S D S Y L R P A A S P R L E S C-term L R D V A S E S V A L F F M L L L D L T A V A G N A A V M A V I A K T K F V F V F H L C L V D L L A A L T L M P L A M L S S S A L F G E V A C R L Y L F L S V C F V S L A I L S V S A I N V E R Y Y Y V V H T L G L V A S V L V G V W V K A L A M A S V P V L G R V S W E S A Y C Q L F V V V F A V L Y F L L P L L L I L V V Y C S M F R V A R V A A M Q H G P L P P H R T F G G G K A A V V L L A V G G Q F L L C W L P Y F S F H L Y V A L S T G Q V E S V V T W I G Y F C F T S N P F F Y G C L N R Q L S K I R G E Q F V
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR61
TM3
3x47 3.47x47 N137
3x50 3.50x50 R140
TM5
5x57 5.57x57 V227
5x61 5.61x61 M231
TM6
6x35 6.35x35 V287
6x36 6.36x36 V288
6x40 6.40x40 V292
H8
8x47 8.47x47 N345