Structure information

TAS2R14

PROTEIN CLASS

Class T2 (Taste 2)

PDB CODE

9W0P

SPECIES

Homo sapiens

RESOLUTION

3.600

PREFERRED CHAIN

R

REFERENCE

10.1038/S41594-026-01786-8

PUBLICATION DATE

April 22, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHLORHEXIDINE F76 ECL1 hydrophobic
CHLORHEXIDINE F82 3.25x25 TM3 hydrophobic
CHLORHEXIDINE L85 3.28x28 TM3 hydrophobic
CHLORHEXIDINE W89 3.32x32 TM3 hydrophobic
CHLORHEXIDINE F175 ECL2 hydrophobic
CHLORHEXIDINE L178 ECL2 hydrophobic
CHLORHEXIDINE I179 5.39x40 TM5 hydrophobic
CHLORHEXIDINE E259 ECL3 polar (charge-assisted hydrogen bond)
CHLORHEXIDINE I262 7.35x34 TM7 hydrophobic
CHLORHEXIDINE I262 7.35x34 TM7 Van der Waals
CHLORHEXIDINE S265 7.38x37 TM7 Van der Waals

Ligands

CHLORHEXIDINE

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Residue Diagrams

S N G L N G I I F E V I L V F T F I S K 1 T A L A I S R I S L V W L I F G S W C V 2 G T A L W V S F H N I V T W I N T L M R 3 V L V L L L V T S V F L F L N I A L I N 4 F M A L S L T F P I F I F V T S T L V I 5 V I T F F L L Y A I F S L S F F I S V W 6 C S H C S P Y A M G M V Q S L I I L N 7
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ICL1 R K I ICL1ECL1 P A L F A ECL1ICL2 N F S N S I F L Y L K W ICL2ECL2 A S I N G Y R R N K T C S S D S S N F T R F S S L ECL2ICL3 K I S G D A S T K A ICL3ECL3 E E ECL3C-term G E P S G H K E F R E S S C-term M G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A R V K K V V L V L L L V T S V F L F L N I A L I N I H I N I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L N L I I L S Q V M G M A Y P S C H S C V L I L G N K K S L S L R Y L R Q A V L L W M F K D
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Residue Table


GPCRdb(A)
GPCRdb(A)
TAS2R14
TM3
3x25 3.25x25 F82
3x28 3.28x28 L85
3x32 3.32x32 W89
TM5
5x40 5.39x40 I179
TM7
7x34 7.35x34 I262
7x37 7.38x37 S265