Structure information

GPR139

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9M42

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

Jan. 21, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Compound 1.1(S) F109 3.33x33 TM3 aromatic (face-to-edge)
Compound 1.1(S) W166 ECL2 polar (hydrogen bond)
Compound 1.1(S) W166 ECL2 Van der Waals
Compound 1.1(S) I169 ECL2 Van der Waals
Compound 1.1(S) R244 6.51x51 TM6 polar (charge-assisted hydrogen bond)
Compound 1.1(S) M247 6.54x54 TM6 Van der Waals
Compound 1.1(S) I248 6.55x55 TM6 hydrophobic

Ligands

Compound 1.1(S)

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Residue Diagrams

I N A P L G L C L L L S Y Y V V P V F 1 L A L A A A D I L V L F F I V F V D F L 2 P V T I W I S T H I S S F E L V E I I K 3 T R K V I V S V Y I T C F L T S I P Y 4 N L I F F I S C P V L Y V T F C H I W I L 5 F T I T S I F A T L W A P R I I M I L Y 6 F F N I A T N L L A L M N A I D S M I 7
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ICL1 Q L V A R R Q ICL1ECL1 N M Q ECL1ICL2 P L K Y H T V S ICL2ECL2 W P N I W T E D Y I S ECL2ICL3 S N F R L R ICL3ECL3 A P I Q ECL3N-term M E H T H A H L A A N S S L S W W S P G S A C G L G N-termC-term K C Q K Q P V Q F Y T N H N F S I T S S P W I S P A N S H C I K M L V Y Q Y D K N G K P I K V S P C-term F V P V V Y Y S L L L C L G L P A N I L T V I I L S K S S Y N Y L L A L A A A D I L V L F F I V F V D F L L E D F I L M P Q V P D K I I E V L E F S S I H T S I W I T V P L T I D R Y I A V C H Y P A R T R K V I V S V Y I T C F L T S I P Y Y W T S V H H V L I W I H C F T V Y L V P C S I F F I L N S I I V Y K L R R K G Y S T G K T T A I L F T I T S I F A T L W A P R I I M I L Y H L Y G N R W L V H I M S D I A N M L A L L N T A I N F F L Y C F I S K R A A A F F F R T M T L K A
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR139
TM3
3x33 3.33x33 F109
TM6
6x51 6.51x51 R244
6x54 6.54x54 M247
6x55 6.55x55 I248