Structure information

EP1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9M1H

SPECIES

Homo sapiens

RESOLUTION

2.550

PREFERRED CHAIN

A

REFERENCE

10.1073/PNAS.2423840122

PUBLICATION DATE

April 30, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PGE<sub>2</sub> P39 1.39x39 TM1 polar (hydrogen bond with backbone)
PGE<sub>2</sub> P39 1.39x39 TM1 Van der Waals
PGE<sub>2</sub> S42 1.42x42 TM1 polar (hydrogen bond)
PGE<sub>2</sub> M43 1.43x43 TM1 Van der Waals
PGE<sub>2</sub> M43 1.43x43 TM1 hydrophobic
PGE<sub>2</sub> G87 2.53x53 TM2 Van der Waals
PGE<sub>2</sub> G87 2.53x53 TM2 polar (hydrogen bond with backbone)
PGE<sub>2</sub> H88 2.54x54 TM2 polar (hydrogen bond)
PGE<sub>2</sub> G92 2.58x58 TM2 Van der Waals
PGE<sub>2</sub> V95 2.61x61 TM2 hydrophobic
PGE<sub>2</sub> V95 2.61x61 TM2 Van der Waals
PGE<sub>2</sub> Y99 2.65x65 TM2 Van der Waals
PGE<sub>2</sub> Y99 2.65x65 TM2 polar (hydrogen bond)
PGE<sub>2</sub> M117 3.32x32 TM3 Van der Waals
PGE<sub>2</sub> M117 3.32x32 TM3 hydrophobic
PGE<sub>2</sub> T186 ECL2 Van der Waals
PGE<sub>2</sub> W187 ECL2 Van der Waals
PGE<sub>2</sub> W310 6.48x48 TM6 Van der Waals
PGE<sub>2</sub> W310 6.48x48 TM6 hydrophobic
PGE<sub>2</sub> F334 7.36x35 TM7 hydrophobic
PGE<sub>2</sub> F334 7.36x35 TM7 Van der Waals
PGE<sub>2</sub> V337 7.39x38 TM7 hydrophobic
PGE<sub>2</sub> V337 7.39x38 TM7 Van der Waals
PGE<sub>2</sub> R338 7.40x39 TM7 polar (charge-assisted hydrogen bond)
PGE<sub>2</sub> S341 7.43x42 TM7 polar (hydrogen bond)
PGE<sub>2</sub> Q344 7.46x46 TM7 polar (hydrogen bond)
PGE<sub>2</sub> Q344 7.46x46 TM7 Van der Waals

Ligands

PGE<sub>2</sub>

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Residue Diagrams

L N S V A G L T M S F I P L A P S 1 A S L L A T D L A G H V I P G A L V L R 2 G C G L L L P C L G F F V M C G G L F H 3 A R L A L A A V A A V A L A V A L L P L 4 L T N C V L A A L L A V L G L S A F L G 5 V G I M V V S C I C W S P M L V L V A L 6 W P D L I Q N W S A L R V A L F L P R 7
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ICL1 G R L R ICL1ECL1 A G R A P A ECL1ICL2 P L L H A A R V ICL2ECL2 V G R Y E L Q Y P G T W C F I G L G P P G ECL2ICL3 P P P A S G P D S R R R W G A H G P R S A S A S S A S S I A S A S T F F G G S R S S G S A ICL3ECL3 W S S T S ECL3N-term M S P C G P L N L S L A G E A T T C A A P W V P N T S A V P P S G A N-termC-term G P A G L G L T P S A W E A S S L R S S R H S G L S H F C-term S P A L P I F S M T L G A V S N L L A L A L L A Q A A R R R S A A T F L L F V A S L L A T D L A G H V I P G A L V L R L Y T G G A C H F L G G C M V F F G L C P L L L G C G M A V E R C V G V T R S V A R A R L A L A A V A A V A L A V A L L P L A R G W R Q A L L A G L F A S L G L V A L L A A L V C N T L S G L A L L R A R W R R R S R R R R A R A H D V E M V G Q L V G I M V V S C I C W S P M L V L V A L A V G G L Q R P L F L A V R L A S W N Q I L D P W V Y I L L R Q A L L R R A G V L R Q L L P P A K G
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Residue Table


GPCRdb(A)
GPCRdb(A)
EP1 receptor
TM1
1x39 1.39x39 P39
1x42 1.42x42 S42
1x43 1.43x43 M43
TM2
2x53 2.53x53 G87
2x54 2.54x54 H88
2x58 2.58x58 G92
2x61 2.61x61 V95
2x65 2.65x65 Y99
TM3
3x32 3.32x32 M117
TM6
6x48 6.48x48 W310
TM7
7x35 7.36x35 F334
7x38 7.39x38 V337
7x39 7.40x39 R338
7x42 7.43x42 S341
7x46 7.46x46 Q344