Structure information

GPR4

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9LMP

SPECIES

Homo sapiens

RESOLUTION

2.650

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

July 2, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
NE 52-QQ57 P20 1.35x35 TM1 hydrophobic
NE 52-QQ57 Y24 1.39x39 TM1 polar (hydrogen bond)
NE 52-QQ57 Y24 1.39x39 TM1 Van der Waals
NE 52-QQ57 W73 2.60x60 TM2 aromatic (face-to-face)
NE 52-QQ57 W73 2.60x60 TM2 Van der Waals
NE 52-QQ57 Y76 2.63x63 TM2 polar (hydrogen bond)
NE 52-QQ57 F77 2.64x64 TM2 Van der Waals
NE 52-QQ57 F77 2.64x64 TM2 aromatic (edge-to-face)
NE 52-QQ57 H80 2.67x67 TM2 Van der Waals
NE 52-QQ57 D81 ECL1 Van der Waals
NE 52-QQ57 F97 3.32x32 TM3 hydrophobic
NE 52-QQ57 Y163 ECL2 Van der Waals
NE 52-QQ57 F167 ECL2 hydrophobic
NE 52-QQ57 F167 ECL2 Van der Waals
NE 52-QQ57 C168 45.50x50 ECL2 Van der Waals
NE 52-QQ57 F169 45.51x51 ECL2 Van der Waals
NE 52-QQ57 F169 45.51x51 ECL2 hydrophobic
NE 52-QQ57 H369 7.36x35 TM7 Van der Waals
NE 52-QQ57 L372 7.39x38 TM7 Van der Waals
NE 52-QQ57 L372 7.39x38 TM7 hydrophobic

Ligands

NE 52-QQ57

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Residue Diagrams

C N T P L G V G I V F I Y L S P P F L H 1 M N L S I A D L L Y I C T L P L W V D Y 2 C C L F A I S I Y I N T Y F I F G F L K 3 A V A V S S V V W A T E L G A N S A P L 4 Y S L L M L A W P F L F G V F V R Y L N M 5 L S L I A I V L V C F A P Y H V L L L S 6 I P D A V C N L S T F A L S S H Y A S 7
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ICL1 R ICL1ECL1 D N W I H ECL1ICL2 P L R F A R L R ICL2ECL2 D E L F R D R Y N H T F C F E K F P M ECL2ICL3 S V S T ICL3ECL3 W D ECL3N-term M G N H T W E G C H V N-termC-term F L A S D K P Q E M A N A S L T L E T P L T S K R N S T A K A M T G S W A A T P P S Q G D Q V Q L K M L P P A Q C-term D S R V D H L F P P S L Y I F V I G V G L P T N C L A L W A A Y R Q V Q Q N E L G V Y L M N L S I A D L L Y I C T L P L W V D Y F L H H G P G S C K L F G F I F Y T N I Y I S I A F L C C I S V D R Y L A V A H R V K T A V A V S S V V W A T E L G A N S A P L F H E G W V A W M N L Y R V F V G F L F P W A L M L L S Y R G I L R A V R G E R Q E K A K I K R L A L S L I A I V L V C F A P Y H V L L L S R S A I Y L G R P C G F E E R V F S A Y H S S L A F T S L N C V A D P I L Y C L V N E G V A K L L R A R S D A L H N
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR4
TM1
1x35 1.35x35 P20
1x39 1.39x39 Y24
TM2
2x60 2.60x60 W73
2x63 2.63x63 Y76
2x64 2.64x64 F77
2x67 2.67x67 H80
TM3
3x32 3.32x32 F97
ECL2
45x50 45.50x50 C168
45x51 45.51x51 F169
TM7
7x35 7.36x35 H269
7x38 7.39x38 L272