Structure information

DP1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9E9S

SPECIES

Homo sapiens

RESOLUTION

2.680

PREFERRED CHAIN

D

REFERENCE

10.1038/S41467-025-64002-Z

PUBLICATION DATE

Sept. 3, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PGD<sub>2</sub> K76 2.54x54 TM2 polar (charge-assisted hydrogen bond)
PGD<sub>2</sub> L79 2.57x57 TM2 hydrophobic
PGD<sub>2</sub> L79 2.57x57 TM2 Van der Waals
PGD<sub>2</sub> S80 2.58x58 TM2 Van der Waals
PGD<sub>2</sub> V83 2.61x61 TM2 hydrophobic
PGD<sub>2</sub> V83 2.61x61 TM2 Van der Waals
PGD<sub>2</sub> Y87 2.65x65 TM2 polar (hydrogen bond)
PGD<sub>2</sub> Y87 2.65x65 TM2 Van der Waals
PGD<sub>2</sub> M112 3.32x32 TM3 Van der Waals
PGD<sub>2</sub> M112 3.32x32 TM3 hydrophobic
PGD<sub>2</sub> F115 3.35x35 TM3 hydrophobic
PGD<sub>2</sub> G116 3.36x36 TM3 Van der Waals
PGD<sub>2</sub> T181 ECL2 Van der Waals
PGD<sub>2</sub> T181 ECL2 polar (hydrogen bond)
PGD<sub>2</sub> W182 ECL2 Van der Waals
PGD<sub>2</sub> W182 ECL2 hydrophobic
PGD<sub>2</sub> L306 7.36x35 TM7 Van der Waals
PGD<sub>2</sub> L306 7.36x35 TM7 hydrophobic
PGD<sub>2</sub> L309 7.39x38 TM7 hydrophobic
PGD<sub>2</sub> L309 7.39x38 TM7 Van der Waals
PGD<sub>2</sub> R310 7.40x39 TM7 polar (charge-assisted hydrogen bond)
PGD<sub>2</sub> L312 7.42x41 TM7 hydrophobic
PGD<sub>2</sub> L312 7.42x41 TM7 Van der Waals
PGD<sub>2</sub> S313 7.43x42 TM7 Van der Waals
PGD<sub>2</sub> S316 7.46x46 TM7 Van der Waals

Ligands

PGD<sub>2</sub>

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Residue Diagrams

L N G L L G T S F L V G G M V A S 1 C G L T V T D L L G K C L L S P V V L A 2 A L L Q L T S S L G F F S M F F A F A Q 3 G A L V A P V V S A F S L A F C A L P F 4 G L N C L V T A L V L L A M L S S Y L V 5 A L M T V L F T M C S L P V I Y R A Y Y 6 W P D V I S I V S L F R L A R L D E A 7
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ICL1 G L G W C S R R P L R P L P ICL1ECL1 R S L R V L A ECL1ICL2 P F F Y R R H I ICL2ECL2 F G K F V Q Y C P G T W C F I Q M V H E E G S L S V ECL2ICL3 C A E P R A D G R E ICL3ECL3 D V K E K N ECL3N-term M K S P F Y R C Q N T T S V E K G N N-termC-term R P L R Y R S R C S N S T N M E S S L C-term S A V M G G V L F S T G L L G N L L A L G L L A R S S V F Y M L V C G L T V T D L L G K C L L S P V V L A A Y A Q N P A L D N S L C Q A F A F F M S F F G L S S T L Q L L A M A L E C W L S L G H T L R L G A L V A P V V S A F S L A F C A L P F M G L G Y S V L Y S S L M A L L V L A T V L C N L G A M R N L Y A M H R R L Q R H P R S C T R D A S P Q P L E E L D H L L L L A L M T V L F T M C S L P V I Y R A Y Y G A F K R T S E E A E D L R A L R F L S V I S I V D P W I F I I F R S P F F H V F R I K I F I
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Residue Table


GPCRdb(A)
GPCRdb(A)
DP1 receptor
TM2
2x54 2.54x54 K76
2x57 2.57x57 L79
2x58 2.58x58 S80
2x61 2.61x61 V83
2x65 2.65x65 Y87
TM3
3x32 3.32x32 M112
3x35 3.35x35 F115
3x36 3.36x36 G116
TM7
7x35 7.36x35 L306
7x38 7.39x38 L309
7x39 7.40x39 R310
7x41 7.42x41 L312
7x42 7.43x42 S313
7x46 7.46x46 S316