Structure information

DP1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8ZW0

SPECIES

Homo sapiens

RESOLUTION

2.720

PREFERRED CHAIN

D

REFERENCE

10.1073/PNAS.2501902122

PUBLICATION DATE

May 28, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PGD<sub>2</sub> L79 2.57x57 TM2 hydrophobic
PGD<sub>2</sub> S80 2.58x58 TM2 polar (hydrogen bond)
PGD<sub>2</sub> S80 2.58x58 TM2 Van der Waals
PGD<sub>2</sub> V83 2.61x61 TM2 hydrophobic
PGD<sub>2</sub> V83 2.61x61 TM2 Van der Waals
PGD<sub>2</sub> Y87 2.65x65 TM2 Van der Waals
PGD<sub>2</sub> M112 3.32x32 TM3 hydrophobic
PGD<sub>2</sub> M112 3.32x32 TM3 Van der Waals
PGD<sub>2</sub> T181 ECL2 polar (hydrogen bond)
PGD<sub>2</sub> T181 ECL2 Van der Waals
PGD<sub>2</sub> W182 ECL2 Van der Waals
PGD<sub>2</sub> W182 ECL2 polar (hydrogen bond)
PGD<sub>2</sub> L306 7.36x35 TM7 Van der Waals
PGD<sub>2</sub> L306 7.36x35 TM7 hydrophobic
PGD<sub>2</sub> L309 7.39x38 TM7 hydrophobic
PGD<sub>2</sub> R310 7.40x39 TM7 polar (charge-assisted hydrogen bond)
PGD<sub>2</sub> S313 7.43x42 TM7 Van der Waals

Ligands

PGD<sub>2</sub>

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Residue Diagrams

L N G L L G T S F L V G G M V A S 1 C G L T V T D L L G K C L L S P V V L A 2 A L L Q L T S S L G F F S M F F A F A Q 3 G A L V A P V V S A F S L A F C A L P F 4 G L N C L V T A L V L L A M L S S Y L V 5 A L M T V L F T M C S L P V I Y R A Y Y 6 W P D V I S I V S L F R L A R L D E A 7
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ICL1 G L G W C S R R P L R P L P ICL1ECL1 R S L R V L A ECL1ICL2 P F F Y R R H I ICL2ECL2 F G K F V Q Y C P G T W C F I Q M V H E E G S L S V ECL2ICL3 C A E P R A D G R E ICL3ECL3 D V K E K N ECL3N-term M K S P F Y R C Q N T T S V E K G N N-termC-term R P L R Y R S R C S N S T N M E S S L C-term S A V M G G V L F S T G L L G N L L A L G L L A R S S V F Y M L V C G L T V T D L L G K C L L S P V V L A A Y A Q N P A L D N S L C Q A F A F F M S F F G L S S T L Q L L A M A L E C W L S L G H T L R L G A L V A P V V S A F S L A F C A L P F M G L G Y S V L Y S S L M A L L V L A T V L C N L G A M R N L Y A M H R R L Q R H P R S C T R D A S P Q P L E E L D H L L L L A L M T V L F T M C S L P V I Y R A Y Y G A F K R T S E E A E D L R A L R F L S V I S I V D P W I F I I F R S P F F H V F R I K I F I
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Residue Table


GPCRdb(A)
GPCRdb(A)
DP1 receptor
TM2
2x57 2.57x57 L79
2x58 2.58x58 S80
2x61 2.61x61 V83
2x65 2.65x65 Y87
TM3
3x32 3.32x32 M112
TM7
7x35 7.36x35 L306
7x38 7.39x38 L309
7x39 7.40x39 R310
7x42 7.43x42 S313