Structure information

GPER

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XOF

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

April 10, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Lys05 L137 3.32x32 TM3 hydrophobic
Lys05 W272 6.48x48 TM6 hydrophobic
Lys05 E275 6.51x51 TM6 polar (charge-assisted hydrogen bond)
Lys05 H282 6.58x58 TM6 Van der Waals
Lys05 H300 ECL3 aromatic (face-to-edge)
Lys05 H300 ECL3 polar (hydrogen bond)
Lys05 H300 ECL3 Van der Waals
Lys05 A301 ECL3 Van der Waals

Ligands

Lys05

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Residue Diagrams

I N G V F G I P F L F I T Y L C S L F L 1 I N L A V A D L I L V A D S L I E V F N 2 W T L F F V S S Y M N V Q L F L S M F T 3 A R L S C G L I W M A S V S A T L V P F 4 Y C L G I I A F P V I F G L T V E L W Q V 5 L A V V L V F F V C W L P E N V F I S V 6 L P N L C S N S F A A L N V I H G T L 7
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ICL1 R E K M ICL1ECL1 Y Y D I ECL1ICL2 A M R C S L F R ICL2ECL2 T D E A C F C F A D ECL2ICL3 H R G L R P R ICL3ECL3 P G A A P C ECL3N-term M D V T S Q A R G V G L E M Y P G T A Q P A A P N T T S P E L N L S H P L L G T A L A N G T G E L S N-termC-term T N L P A L N R F C H A A L K A V I P D S T E Q S D V R F S S A V C-term E H Q Q Y V I G L F L S C L Y T I F L F P I G F V G N I L I L V V N I S F T I P D L Y F I N L A V A D L I L V A D S L I E V F N L H E R A V L C T F M S L F L Q V N M Y S S V F F L T W M S F D R Y I A L A R T K H H A R L S C G L I W M A S V S A T L V P F T A V H L Q H V R E V Q W L E V T L G F I V P F A I I G L C Y S L I V R V L V R A H R R Q K A L R M I L A V V L V F F V C W L P E N V F I S V H L L Q R T Q K Q S F R H A H P L T G H I V N L A A F S N S C L N P L I Y S F L G E T L R L K F R D K Y I E Q
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPER
TM3
3x32 3.32x32 L137
TM6
6x48 6.48x48 W272
6x51 6.51x51 E275
6x58 6.58x58 H282