Structure information

κ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8DZQ

SPECIES

Homo sapiens

RESOLUTION

2.820

PREFERRED CHAIN

A

REFERENCE

10.1038/S41586-023-06030-7

PUBLICATION DATE

May 3, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL180126 L135 3.29x29 TM3 hydrophobic
CHEMBL180126 M142 3.36x36 TM3 hydrophobic
CHEMBL180126 W287 6.48x48 TM6 hydrophobic
CHEMBL180126 I294 6.55x55 TM6 hydrophobic
CHEMBL180126 Y312 7.35x34 TM7 hydrophobic
CHEMBL180126 I316 7.39x38 TM7 hydrophobic
CHEMBL180126 Y320 7.43x42 TM7 hydrophobic

Ligands

CHEMBL180126

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Residue Diagrams

S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7
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ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
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Residue Table


GPCRdb(A)
GPCRdb(A)
κ receptor
TM3
3x29 3.29x29 I135
3x36 3.36x36 M142
TM6
6x48 6.48x48 W287
6x55 6.55x55 I294
TM7
7x34 7.35x34 Y312
7x38 7.39x38 I316
7x42 7.43x42 Y320