Structure information

MRGPRX2

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7VV4

SPECIES

Homo sapiens

RESOLUTION

2.970

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-021-04077-Y

PUBLICATION DATE

Dec. 1, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
linear cortistatin-14 E164 4.60x60 TM4 polar (charge-assisted hydrogen bond)
linear cortistatin-14 C168 4.64x64 TM4 polar (hydrogen bond with backbone)
linear cortistatin-14 C168 4.64x64 TM4 Van der Waals
linear cortistatin-14 G169 ECL2 Van der Waals
linear cortistatin-14 F170 ECL2 hydrophobic
linear cortistatin-14 F170 ECL2 Van der Waals
linear cortistatin-14 S177 5.33x33 TM5 polar (hydrogen bond)
linear cortistatin-14 S177 5.33x33 TM5 polar (hydrogen bond with backbone)
linear cortistatin-14 D184 5.40x40 TM5 polar (charge-assisted hydrogen bond)
linear cortistatin-14 W243 6.55x55 TM6 hydrophobic
linear cortistatin-14 W243 6.55x55 TM6 Van der Waals
linear cortistatin-14 W248 6.60x60 TM6 Van der Waals
linear cortistatin-14 F257 7.31x30 TM7 hydrophobic
linear cortistatin-14 F257 7.31x30 TM7 Van der Waals
linear cortistatin-14 H261 7.35x34 TM7 Van der Waals

Ligands

linear cortistatin-14

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Residue Diagrams

G N G V L G V L A I F L I L F V P I L T 1 L S L A G A D F L F L C F Q I I N C L V 2 T S L M S L G A L Y A C T M V T T F F S 3 S A V V C V L L W A L S L L L S I L E G 4 S S G C L V M F L F I L W A A T I F D F 5 L L T V L V F L L C G L P F G I Q W F L 6 I P N A S S N L S S L V V S V P H I H 7
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ICL1 R R ICL1ECL1 I S I N F ECL1ICL2 P I W Y R C R R ICL2ECL2 G F L F S D G ECL2ICL3 S R G L ICL3ECL3 K D S D V ECL3N-term M D P T T P A W G T E S T T V N G N D Q A L L L L C G K E N-termC-term R K Q W R L Q Q P I L K L A L Q R A L Q D I A E V D H S E G C F R Q G T P E M S R S S L V C-term T L I P V F L I L F I A L V G L V G N G F V L W L L G F R M N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P R H L S A V V C V L L W A L S L L L S I L E G K F C D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G P L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S F
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Residue Table


GPCRdb(A)
GPCRdb(A)
MRGPRX2
TM4
4x60 4.60x60 E164
4x64 4.64x64 C168
TM5
5x33 5.33x33 S177
5x40 5.40x40 D184
TM6
6x55 6.55x55 W243
6x60 6.60x60 W248
TM7
7x30 7.31x30 F257
7x34 7.35x34 H261