Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7IOS

SPECIES

Homo sapiens

RESOLUTION

2.380

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

May 20, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL1524252 N39 2.37x37 TM2 polar (hydrogen bond)
CHEMBL1524252 N39 2.37x37 TM2 Van der Waals
CHEMBL1524252 T41 2.39x39 TM2 Van der Waals
CHEMBL1524252 N42 2.40x40 TM2 polar (hydrogen bond)
CHEMBL1524252 N42 2.40x40 TM2 polar (hydrogen bond)
CHEMBL1524252 V45 2.43x43 TM2 Van der Waals
CHEMBL1524252 I98 3.46x46 TM3 Van der Waals
theophylline F168 45.52x52 ECL2 aromatic (face-to-face)
CHEMBL1524252 A231 6.33x33 TM6 hydrophobic
CHEMBL1524252 A231 6.33x33 TM6 Van der Waals
CHEMBL1524252 A235 6.37x37 TM6 Van der Waals
CHEMBL1524252 A235 6.37x37 TM6 hydrophobic
theophylline L249 6.51x51 TM6 hydrophobic
theophylline N253 6.55x55 TM6 polar (hydrogen bond)
theophylline N253 6.55x55 TM6 polar (hydrogen bond)
theophylline M270 7.35x34 TM7 Van der Waals
theophylline I274 7.39x38 TM7 hydrophobic
theophylline I274 7.39x38 TM7 Van der Waals
CHEMBL1524252 I292 8.47x47 H8 hydrophobic
CHEMBL1524252 I292 8.47x47 H8 Van der Waals
CHEMBL1524252 E294 8.49x49 H8 Van der Waals

Ligands

CHEMBL1524252

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theophylline

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM2
2x37 2.37x37 N39
2x39 2.39x39 T41
2x40 2.40x40 N42
2x43 2.43x43 V45
TM3
3x46 3.46x46 I98
ECL2
45x52 45.52x52 F168
TM6
6x33 6.33x33 A231
6x37 6.37x37 L235
6x51 6.51x51 L249
6x55 6.55x55 N253
TM7
7x34 7.35x34 M270
7x38 7.39x38 I274
H8
8x47 8.47x47 I292
8x49 8.49x49 E294