Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7IOB

SPECIES

Homo sapiens

RESOLUTION

2.110

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

May 20, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
FU35-42 N36 12.49x49 ICL1 polar (hydrogen bond with backbone)
FU35-42 N36 12.49x49 ICL1 Van der Waals
FU35-42 L37 12.50x50 ICL1 Van der Waals
FU35-42 N39 2.37x37 TM2 Van der Waals
FU35-42 N39 2.37x37 TM2 polar (hydrogen bond)
FU35-42 T41 2.39x39 TM2 Van der Waals
FU35-42 N42 2.40x40 TM2 polar (hydrogen bond)
FU35-42 N42 2.40x40 TM2 polar (hydrogen bond)
FU35-42 V45 2.43x43 TM2 Van der Waals
theophylline F168 45.52x52 ECL2 aromatic (face-to-face)
FU35-42 A231 6.33x33 TM6 Van der Waals
FU35-42 A231 6.33x33 TM6 hydrophobic
FU35-42 S234 6.36x36 TM6 Van der Waals
FU35-42 A235 6.37x37 TM6 Van der Waals
FU35-42 A235 6.37x37 TM6 hydrophobic
theophylline L249 6.51x51 TM6 hydrophobic
theophylline N253 6.55x55 TM6 polar (hydrogen bond)
theophylline N253 6.55x55 TM6 polar (hydrogen bond)
theophylline I274 7.39x38 TM7 hydrophobic
theophylline I274 7.39x38 TM7 Van der Waals
FU35-42 I292 8.47x47 H8 Van der Waals
FU35-42 I292 8.47x47 H8 hydrophobic

Ligands

FU35-42

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theophylline

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
ICL1
12x49 12.49x49 N36
12x50 12.50x50 L37
TM2
2x37 2.37x37 N39
2x39 2.39x39 T41
2x40 2.40x40 N42
2x43 2.43x43 V45
ECL2
45x52 45.52x52 F168
TM6
6x33 6.33x33 A231
6x36 6.36x36 S234
6x37 6.37x37 L235
6x51 6.51x51 L249
6x55 6.55x55 N253
TM7
7x38 7.39x38 I274
H8
8x47 8.47x47 I292