Structure information

CCR4

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

11TK

SPECIES

Homo sapiens

RESOLUTION

3.540

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

April 1, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AZD2098 L64 1.57x57 TM1 hydrophobic
AZD2098 L78 2.43x43 TM2 hydrophobic
AZD2098 A355 6.33x33 TM6 hydrophobic
AZD2098 M358 6.36x36 TM6 hydrophobic
AZD2098 Y419 7.53x53 TM7 hydrophobic
AZD2098 E424 ICL4 Van der Waals
AZD2098 E424 ICL4 polar (hydrogen bond with backbone)
AZD2098 K425 8.49x49 H8 polar (hydrogen bond with backbone)
AZD2098 K425 8.49x49 H8 Van der Waals
AZD2098 F426 8.50x50 H8 Van der Waals
AZD2098 F426 8.50x50 H8 aromatic (face-to-face)

Ligands

AZD2098

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Residue Diagrams

S N G L L G F V F V L S Y L P P L F L E 1 L N L A I S D L L F V F S L P F W G Y Y 2 L M V F F I G S Y F G V L Y M W S I M K 3 G V I T S L A T W S V A V F A S L P G 4 Y C F L M I G L P I V L G L I N I E L S S 5 F A V V V L F L G F W T P Y N I V L F L 6 I P N L C C H V F A L T E T A Q I A Y 7
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ICL1 K R L R ICL1ECL1 Q W V F ECL1ICL2 A V F S L R A R ICL2ECL2 T C Y T E R N H T Y C K T K Y S L ECL2ICL3 K N ICL3ECL3 L Q ECL3N-term M N P T D I A D T T L D E S I Y S N Y Y L Y E S I P K P C T N-termC-term T C R G L F V L C Q Y C G L L Q I Y S A D T P S S S Y T Q S T M D H D L H D A L C-term K E G I K A F G E L F L P P L Y S L V F V F G L L G N S V V V L V L F K Y S M T D V Y L L N L A I S D L L F V F S L P F W G Y Y A A D G L G L C K M I S W M Y L V G F Y S G I F F V M L M S I D R Y L A I V H T L T Y G V I T S L A T W S V A V F A S L P G F L F S N S T T W K V L S S L E I N I L G L V I P L G I M L F C Y S M I I R T L Q H C E K K N K A V K M I F A V V V L F L G F W T P Y N I V L F L E T L V E L E V D C T F E R Y L D Y A I Q A T E T L A F V H C C L N P I I Y F F L G E K I L Q F R K Y L F K
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR4
TM1
1x57 1.57x57 L64
TM2
2x43 2.43x43 L78
TM6
6x33 6.33x33 A240
6x36 6.36x36 M243
TM7
7x53 7.53x53 Y304
H8
8x49 8.49x49 K310
8x50 8.50x50 F311